Reversal agents are defined as any drug used to reverse the effects of anesthetics, narcotics or potentially toxic agents.

  • Activated charcoal with sorbitol
  • Theophylline or Caffeine
  • Antimuscarinic drugs (e.g. Atropine)
  • Beta blocker
  • Calcium chloride
  • Calcium gluconate
  • Chelators such as EDTA, dimercaprol (BAL), penicillamine, and 2,3-dimercaptosuccinic acid (DMSA, succimer)
  • Cyanide antidotes (hydroxocobalamin, amyl nitrite, sodium nitrite, or thiosulfate)
  • Cyproheptadine
  • Deferoxamine mesylate
  • Digoxin Immune Fab antibody (Digibind and Digifab)
  • Diphenhydramine hydrochloride and benztropine mesylate
  • 100% Ethanol or fomepizole
  • Flumazenil
  • 100% oxygen or hyperbaric oxygen therapy (HBOT)
  • Idarucizumab
  • Insulin + Glucagon
  • Leucovorin
  • Methylene blue
  • Naloxone hydrochloride
  • N-acetylcysteine
  • Octreotide
  • Pralidoxime chloride (2-PAM)
  • Protamine sulfate
  • Prussian blue
  • Physostigmine sulfate
  • Pyridoxine
  • Phytomenadione (vitamin K) and fresh frozen plasma
  • Sodium bicarbonate
  • V Silibinin
  • Succimer

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